Stimuli-responsive controlled-release system using quadruplex DNA-capped silica nanocontainers

Stimuli-responsive controlled-release system using quadruplex DNA-capped silica nanocontainers

A novel proton-fueled molecular gate-like delivery system has been constructed for controlled cargo release using i-motif quadruplex DNA as caps onto pore outlets of mesoporous silica nanoparticles. Start from simple conformation changes, the i-motif DNA cap can open and close the pore system in smart response to pH stimulus. Importantly, the opening/closing and delivery protocol is highly reve...

Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica nanoparticles.

Enzyme and voltage stimuli are more biologically compatible in the field of stimuli-responsive systems and release systems based on β-cyclodextrin (CD) and ferrocene (Fc) have attracted much attention. Herein, mesoporous silica nanoparticles (MSNs) have been functionalized with the ferrocenyl moiety (Fc) which interacts with β-cyclodextrin (β-CD) to form an inclusion complex on the opening of t...

A glucose-responsive controlled release system using glucose oxidase-gated mesoporous silica nanocontainers.

A glucose-responsive controlled-release system based on the competitive combination between glucose oxidase, glucosamine and glucose has been described, which exhibits perfect controlled release properties and high selectivity for glucose over other monosaccharides. This paved the way for a new generation of stimuli-responsive delivery systems.

Antitumoral drug amidase-responsive controlled release on intracellular media using gluconamide-capped mesoporous silica nanoparticles

Enzyme-responsive snap-top covered silica nanocontainers.

Mesoporous silica nanoparticles coated with molecular valves hold the promise to encapsulate a payload of therapeutic compounds, to transport them to specific locations in the body, and to release them in response to either external or cellular stimuli. Sequestering drug molecules serves the dual purpose of protecting the payload from enzymatic degradation, while reducing the undesired side-eff...